Fwd: Periductal stromal sarcoma of breast with lipoblast-like cells: A case report with review of literature.

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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Wed, Jul 9, 2008 at 5:03 PM
Subject: Periductal stromal sarcoma of breast with lipoblast-like cells: A case report with review of literature.
To: mesothelioma77@gmail.com


[1]Indian J Pathol Microbiol. 2008 Apr; 51(2): 252-4
Rao AC, Geetha V, Khurana A

The specialized mesenchyme of the breast is the seat of neoplasms with distinct morphology, though with considerable overlap due to the ever increasing number of variants. This article seeks to describe the morphologic features of one such rare neoplasm. A 35-year-old female patient presented with a breast lump that was subsequently excised. Morphological assessment and immunohistochemistry were performed and a diagnosis of periductal stromal sarcoma with lipoblast-like cells (pseudolipoblasts), was made. Being an unusual finding in a rare entity of intermediate grade, it has to be considered, before rendering a diagnosis of a malignant, higher-grade neoplasm.



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Source: http://www.hubmed.org/display.cgi?uids=18603698
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Fwd: The Role of Platelet-Derived Endothelial Cell Growth Factor/Thymidine Phosphorylase in Tumor Behavior.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Mon, Jul 7, 2008 at 2:39 PM
Subject: The Role of Platelet-Derived Endothelial Cell Growth Factor/Thymidine Phosphorylase in Tumor Behavior.
To: mesothelioma77@gmail.com


[1]Nucleosides Nucleotides Nucleic Acids. 2008 Jun; 27(6): 681-691
Bijnsdorp IV, de Bruin M, Laan AC, Fukushima M, Peters GJ

Platelet-derived endothelial cell growth-factor (PD-ECGF) is similar to the pyrimidine enzyme thymidine phosphorylase (TP). A high TP expression at tumor sites is correlated with tumor growth, induction of angiogenesis, and metastasis. Therefore, high TP is most likely associated with a poor prognosis. TP is not only expressed in tumor cells but also in tumor surrounding tissues, such as tumor infiltrating macrophages. TP catalyzes the conversion of thymidine to thymine and doxyribose-1-phosphate (dR-1-P). The latter in its parent form or in its sugar form, deoxyribose (dR) may play a role in the induction of angiogenesis. It may modulate cellular energy metabolism or be a substrate in a chemical reaction generating reactive oxygen species. L-deoxyribose (L-dR) and thymidine phosphorylase inhibitor (TPI) can reverse these effects. The mechanism of TP induction is not yet completely clear, but TNF, IL10 and other cytokines have been clearly shown to induce its expression. The various complex interactions of TP give it an essential role in cellular functioning and, hence, it is an ideal target in cancer therapy.



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Source: http://www.hubmed.org/display.cgi?uids=18600526
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