Graphs Tables for Skin Cancer: 03/16/08

Fwd: Surgical Complications and the Risk Factors of Laparoscopy-Assisted Distal Gastrectomy in Early Gastric Cancer.

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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sun, Mar 16, 2008 at 1:55 AM
Subject: Surgical Complications and the Risk Factors of Laparoscopy-Assisted Distal Gastrectomy in Early Gastric Cancer.
To: mesothelioma77@gmail.com

[1]Ann Surg Oncol. 2008 Mar 14;
Ryu KW, Kim YW, Lee JH, Nam BH, Kook MC, Choi IJ, Bae JM

BACKGROUND: Information on surgical complications of laparoscopy-assisted distal gastrectomy (LADG) and their risk factors is limited in the literature despite increasing popularity of this procedure. This study was performed to identify the surgical complications and their associated risk factors of LADG in early gastric cancer. METHODS: LADG was performed in 347 gastric cancer patients from January 2002 to December 2006 at the Korean National Cancer Center by four surgeons with ample experience of open gastric surgery before LADG. LADG indications for cases of gastric cancer at our institution are preoperatively diagnosed cT1N0 or cT1N1, except in cases with an absolute indication for endoscopic resection. Lymph node dissection of more than D1 + beta was performed in all patients. Intraoperative and postoperative complications were reviewed and their risk factors were retrospectively analyzed by prospective database information. RESULTS: Forty complications occurred in 34 patients (9.8%), but there was no mortality. Intraoperative complications occurred in nine patients (2.6%), and open conversion was performed in eight (2.3%) of these patients. Early and late postoperative complications occurred in 21 (6.1%) and 10 (2.9%) patients, respectively. The most serious complication was vascular injury resulting in bleeding or organ ischemia, which occurred in seven patients. Degree of lymph node dissection and surgical inexperience were found to be risk factors of surgical complication (P = .023, odds ratio 2.832, 95% confidence interval 1.155-6.946 vs. P = .028, odds ratio 2.975, 95% confidence interval 1.127-7.854). CONCLUSIONS: Lymph node dissection during LADG should be performed cautiously to prevent surgical complications like vascular injuries, especially during the surgeon's early learning period.

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Source: http://www.hubmed.org/display.cgi?uids=18340493
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Fwd: A multifunctional androgen receptor screening assay using the high-throughput Hypercyt((R)) flow cytometry system.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sun, Mar 16, 2008 at 1:55 AM
Subject: A multifunctional androgen receptor screening assay using the high-throughput Hypercyt((R)) flow cytometry system.
To: mesothelioma77@gmail.com

[1]Cytometry A. 2008 Mar 13;
Dennis MK, Bowles HJ, Mackenzie DA, Burchiel SW, Edwards BS, Sklar LA, Prossnitz ER, Thompson TA

The androgen receptor (AR) is a steroid hormone receptor which regulates transcription of androgen-sensitive genes and is responsible for the development and maintenance of male secondary sexual characteristics. Chemicals that interfere with AR activity may lead to pathological conditions in androgen-sensitive tissues. A variety of reporter systems have been developed, driven by androgen-sensitive promoters, which screen for chemicals that modulate androgenic activity. We have developed a flexible, high-throughput AR transcriptional activation assay, designated the Multifunctional Androgen Receptor Screening (MARS) assay, to facilitate the identification of novel modulators of AR transcriptional activity using flow cytometry. Androgen-independent human prostate cancer-derived PC3 cells were transiently cotransfected with an expression vector for the wild-type human AR and an androgen-sensitive promoter regulating the expression of destabilized enhanced GFP (dsEGFP). The transfected cells were stimulated with established androgenic and antiandrogenic compounds and assessed for increased or decreased dsEGFP expression. To screen for antagonists of AR transcription, the AR agonist R1881 was coadministered at submaximal concentrations with potential AR antagonists. The assay was formatted for high-throughput screening using the HyperCyt(R) flow cytometry system. Agents with established androgenic and antiandrogenic activity were used for validation of the MARS assay. AR agonists were found to potently induce dsEGFP. Furthermore, AR agonists induced dsEGFP expression in a dose-dependent manner. Alternatively, AR antagonists blocked dsEGFP expression when coadministered with low-dose R1881, which also occurred in a dose-dependent manner. Modulators of AR transcriptional activity can be successfully identified by the MARS assay, utilizing a rapid, flexible, sensitive, and high-throughput format. Dose-response curves can be successfully generated for these compounds, allowing for an assessment of potency. Because of its simplicity and high-throughput compatibility, the MARS assay and HyperCyt(R) system combined with flow cytometric analysis represents a valuable and novel addition to the current repertoire of AR transcriptional activation screening assays. (c) 2008 International Society for Analytical Cytology.

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Source: http://www.hubmed.org/display.cgi?uids=18340645
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Fwd: Check on Welsh schools demanded after ex-teacher’s asbestos death (icWales)

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From: Yahoo! News Search Results for asbestos cancer <rssfwd@rssfwd.com>
Date: Sun, Mar 16, 2008 at 1:56 AM
Subject: Check on Welsh schools demanded after ex-teacher's asbestos death (icWales)
To: mesothelioma77@gmail.com

ALL schools in Wales must be checked for asbestos after the death of a retired teacher was linked to the carcinogenic building material, teachers' leaders and the Welsh Assembly Government said yesterday.

Sat, 15 Mar 2008 06:57:00 GMT

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Source: http://us.rd.yahoo.com/dailynews/rss/search/asbestos+cancer/SIG=14fv6abut/*http%3A//icwales.icnetwork.co.uk/news/wales-news/2008/03/15/check-on-welsh-schools-demanded-after-ex-teacher-s-asbestos-death-91466-20626591/
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Fwd: Checkoff numbers cause for concern?

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Sun, Mar 16, 2008 at 1:55 AM
Subject: Checkoff numbers cause for concern?
To: mesothelioma77@gmail.com

Tri-state taxpayers share the experience of cutting a check to Uncle Sam or getting a return this time of year, but thousands of them also use their income tax filing to boost worthy causes.

Sat, 15 Mar 2008 16:05:57 GMT

Source: http://www.THonline.com/article.cfm?id=194525
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Mesothelioma Diagnosis

Unlike lung cancer, there is no association between mesothelioma and smoking Malignancies involving mesothelial cells in these size cavities are known as malignant mesothelioma, which may be localized or diffuse. Its most basic site is the pleura (outer lining of the lungs and chest cavity), but it may also occur in the peritoneum (the lining of the abdominal cavity) or the pericardium (a sac that surrounds the heart).

In this disease, malignant cells develop in the mesothelium, a protective lining that covers utmost of the size's internal organs.

Mesothelial cells normally line the body cavities, including the pleura, peritoneum, pericardium, and testis. Malignant mesothelioma has also been linked to curing radiation using thorium dioxide and zeolite, a silicate in the soil.

Other symptoms of peritoneal mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia, and fever. Mesothelioma is diagnosed by pathological examination from a biopsy. This is the end of a skill that usually begins with symptoms that send top-notch people to the doctor: a fluid build-up around the lungs (pleural effusions), shortness of breath, suffering in the chest, or aches and or swelling in the abdomen. The X-ray may reveal pleural thickening commonly seen after asbestos exposure and increases suspicion of mesothelioma. A history of exposure to asbestos may increase clinical suspicion for mesothelioma.

Symptoms of mesothelioma may not appear until 20 to 50 years after exposure to asbestos. A physical examination is performed, followed by chest X-ray and often lung function tests. Shortness of breath, cough, and pain in the chest due to an accumulation of fluid in the pleural space are often symptoms of pleural mesothelioma.

Diagnosing mesothelioma is often difficult, because the symptoms are similar to those of a number of other conditions. Malignant mesothelioma is more absolute in men, with a male-to-female ratio of 3:1. Malignant mesothelioma is a rare type of cancer in which malignant cells are found in the sac lining the chest or abdomen.

Exposure to airborne asbestos particles increases one's risk of developing malignant mesothelioma.

Malignant mesothelioma is often just called simply Mesothelioma and is a aptitude of lung cancer that is quite rare. Perfectly malignant mesotheliomas set up complex karyotypes, with extensive aneuploidy and rearrangement of bunch chromosomes. It can also occur in children; however, these cases are not thought to be associated with asbestos exposure.

Malignant mesothelioma has a peak incidence 35-45 years after asbestos exposure.

Utmost people with malignant mesothelioma require worked on jobs where they breathed asbestos. Mesothelioma is a finesse of cancer that is almost always caused by previous exposure to asbestos

There are now a number of cancer treatment options convenient to mesothelioma patients. Extrapleural pneumonectomy for selected patients with very early stage disease may succeed recurrence-free survival, but the impact it has on overall survival is unknownat this time. The covet of radiation curing in pleural mesothelioma has been shown to discharge pain in the majority of patients that are treated. But unfortunately, the duration of symptom control is short-lived. Surgical resection has been relied upon because radiation and chemotherapy let been ineffective undistorted treatments.

Extrapleural pneumonectomy is a more extensive procedure and has a higher mortality rate. Recently, the mortality rate has been lowered to 3.8%. It involves dissection of the parietal pleura; division of the pulmonary vessels; and en bloc resection of the lung, pleura, pericardium, and diaphragm followed by reconstruction. It provides the best local control because it removes the all-out pleural sac along with the lung parenchyma.

With surgery alone, the recurrence rate is very high and super patients die after a few months. At least half the patients who allow local control with surgery make distant metastasis upon autopsy.