Welcome to my New Blog... Graphs Tables for Skin Cancer

Skin Cancer, mesothelioma, Mesothelioma Cancer, Mesothelioma Lwayer
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Tuesday, April 1, 2008

Fwd: Routine Contrast Imaging of Low Pelvic Anastomosis Prior to Closure of Defunctioning Ileostomy: is it Necessary?



---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Fri, Mar 28, 2008 at 3:15 PM
Subject: Routine Contrast Imaging of Low Pelvic Anastomosis Prior to Closure of Defunctioning Ileostomy: is it Necessary?
To: mesothelioma77@gmail.com


[1]J Gastrointest Surg. 2008 Mar 27;
Kalady MF, Mantyh CR, Petrofski J, Ludwig KA

PURPOSE: The purpose of the study was to determine the utility of routine contrast enema prior to ileostomy closure and its impact on patient management in patients with a low pelvic anastomosis. MATERIAL AND METHODS: Two hundred eleven patients had a temporary loop ileostomy constructed to protect a low colorectal or coloanal anastomosis following low anterior resection for cancer (57%) or other disease (12%) or to protect an ileal pouch-anal anastomosis following restorative proctocolectomy (31%). All patients were evaluated by physical examination, proctoscopy, and water-soluble contrast enema prior to ileostomy closure. Imaging results were correlated with the clinical situation to determine the effects on patient management. RESULTS: The mean time from ileostomy creation to closure was 15.6 weeks. Overall, 203 patients (96%) had an uncomplicated course. Eight patients (4%) developed an anastomotic leak, seven of which were diagnosed clinically and confirmed radiographically before planned ileostomy closure. Resolution of the leak was confirmed by follow-up contrast enema. One patient, whose pouchogram revealed a normal anastomosis, clinically developed a leak after ileostomy closure. It is important to note that routine contrast enema examination did not reveal an anastomotic leak or stricture that was not already suspected clinically. CONCLUSIONS: All patients who developed an anastomotic leak in this study were diagnosed clinically, and the diagnosis was confirmed by selective use of radiographic tests. Routine contrast enema evaluation of low pelvic anastomoses before loop ileostomy closure did not provide any additional information that changed patient management. The utility of this routine practice should be questioned.



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Fwd: Soluble Intercellular Adhesion Molecule-1 as a Prognostic Marker for Stage II Colorectal Cancer Patients.



---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Fri, Mar 28, 2008 at 3:15 PM
Subject: Soluble Intercellular Adhesion Molecule-1 as a Prognostic Marker for Stage II Colorectal Cancer Patients.
To: mesothelioma77@gmail.com


[1]Ann Surg Oncol. 2008 Mar 27;
Toiyama Y, Miki C, Inoue Y, Okugawa Y, Koike Y, Yokoe T, Tanaka K, Kusunoki M

BACKGROUND: Soluble intercellular adhesion molecule-1 (sICAM-1) represents a circulating form of ICAM-1 that is constitutively expressed or is inducible, which localizes to the cell surfaces of different cell lines and is related to the metastatic potential of cancer cells. The aim of the present study was to determine the relationships between the preoperative serum concentration of sICAM-1 and clinicopathological features, established tumor markers and prognosis, in colorectal cancer patients. METHODS: One hundred and thirty-eight patients with histologically proven colorectal cancer and 40 normal volunteers were included in this trial. Preoperative serum was collected, and sICAM-1 levels were assayed using a commercially available enzyme-linked immunosorbent assay kit. RESULTS: The mean sICAM-1 level in patients was significantly higher than that in controls, and increased with disease progression. The prognosis of patients with an elevated sICAM-1 level was significantly worse than that of patients with a normal sICAM-1 level. In a Cox multivariate analysis, the strongest prognostic factor in all patients was distant metastasis followed by sICAM-1 level, while in patients with stage II classification, the strongest prognostic factor was serum level of sICAM-1. The prognosis of stage II patients positive for sICAM-1 was comparable to that of stage III patients. CONCLUSIONS: Preoperative sICAM-1 level is an independent prognostic marker for stage II colorectal cancer. Measuring serum sICAM-1 may provide valuable information, especially for stage II patients, when selecting appropriate candidates for adjuvant chemotherapy.



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Fwd: The Edmonton Symptom Assessment System: a 15-year retrospective review of validation studies (1991-2006).



---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sat, Mar 29, 2008 at 3:45 PM
Subject: The Edmonton Symptom Assessment System: a 15-year retrospective review of validation studies (1991-2006).
To: mesothelioma77@gmail.com


[1]Palliat Med. 2008 Mar; 22(2): 111-22
Nekolaichuk C, Watanabe S, Beaumont C

INTRODUCTION: The purpose of this review was to identify and critique validation studies focusing on the Edmonton Symptom Assessment System (ESAS), a commonly used symptom assessment tool for advanced cancer and palliative patients. METHODS: Using a comprehensive literature search, the authors identified and screened 87 publications. Thirteen articles were selected for in-depth review, based on the following inclusion criteria: psychometric studies with a primary focus on the ESAS, 1991-2006 publication dates and peer-reviewed English language publications. RESULTS: Most studies involved cancer patients (n = 11). The ESAS format varied across studies, in terms of scale format, item number, item selection and language. Studies focused on gathering reliability estimates (n = 8), content validity evidence (n = 1), concurrent validity evidence (n = 5), predictive validity evidence (n = 1), and sensitivity and/or specificity (n = 3). None of these studies involved patients' perspectives as a source of validity evidence. DISCUSSION: The use of varying instrument formats and limited psychometric evidence support the need for further ESAS validation studies, including the involvement of patients.



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Fwd: Phase II results for CDP791 in non-small cell lung cancer support further clinical development (Marketwire via Yahoo! Finance)



---------- Forwarded message ----------
From: Yahoo! News Search Results for lung cancer <rssfwd@rssfwd.com>
Date: Mon, Mar 31, 2008 at 4:36 AM
Subject: Phase II results for CDP791 in non-small cell lung cancer support further clinical development (Marketwire via Yahoo! Finance)
To: mesothelioma77@gmail.com


Results provide evidence of CDP791's biological activity. Positive trends were observed on several efficacy endpoints. Data are encouraging in supporting further clinical development of CDP791 in first line non-small cell lung cancer.

Mon, 31 Mar 2008 05:05:00 GMT

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