Graphs Tables for Skin Cancer: 09/05/08

Friday, September 5, 2008

Fwd: Proteomic analysis of anti-tumor effects by Rhizoma Paridis total saponin treatment in HepG2 cells.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Tue, Sep 2, 2008 at 8:26 PM
Subject: Proteomic analysis of anti-tumor effects by Rhizoma Paridis total saponin treatment in HepG2 cells.
To: mesothelioma77@gmail.com

[1]J Ethnopharmacol. 2008 Aug 6;
Cheng ZX, Liu BR, Qian XP, Ding YT, Hu WJ, Sun J, Yu LX

Rhizoma Paridis total saponin (RPTS) had been identified as the major components responsible for the anti-tumor effects of the herb Rhizoma Paridis, which had been used in China for centuries to treat many diseases including tumor. To elucidate the anti-tumor mechanism of RPTS, a proteomic analysis was carried out with RPTS treatment in HepG2 cells. More than 50 proteins showed a significant change between control (0.01% DMSO) and RPTS (IC(50) approximately 10mug/ml) treated cells after 48h. Twelve proteins had been identified by matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) using peptide fingerprinting from 15 protein spots (density difference >2 fold between the control and RPTS-treated group). Among them, six proteins were down-regulated (dUTPase, hnRNP K, GMP synthase, etc.) and six proteins were up-regulated (DNase gamma, Nucleoside diphosphate kinase A, Centrin-2, etc.) by RPTS treatment in HepG2 cells as determined by spot volume (p

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Source: http://www.hubmed.org/display.cgi?uids=18761071
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Fwd: Union criticises insurers over ‘asbestos illness’ (The Herald)

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From: Yahoo! News Search Results for asbestos cancer <rssfwd@rssfwd.com>
Date: Tue, Sep 2, 2008 at 8:26 PM
Subject: Union criticises insurers over 'asbestos illness' (The Herald)
To: mesothelioma77@gmail.com

The trade union Unite has accused the insurance industry of fighting a "virulent" campaign against recognition of the asbestos-related condition pleural plaques.

Mon, 01 Sep 2008 21:41:01 GMT

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Source: http://us.rd.yahoo.com/dailynews/rss/search/asbestos+cancer/SIG=13m5i24t8/*http%3A//www.theherald.co.uk/politics/news/display.var.2438287.0.Union_criticises_insurers_over_asbestos_illness.php
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Fwd: Molecules in focus: Cytosolic phospholipase A(2)-alpha.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Tue, Sep 2, 2008 at 8:26 PM
Subject: Molecules in focus: Cytosolic phospholipase A(2)-alpha.
To: mesothelioma77@gmail.com

[1]Int J Biochem Cell Biol. 2008 Aug 8;
Niknami M, Patel M, Witting PK, Dong Q

Cytosolic phospholipase A(2)-alpha (cPLA(2)-alpha) cleaves its preferred substrate, arachidonic acid, at the sn-2 position of membrane glycerophospholipids. Stimulation of cells with agents that mobilize intracellular calcium and/or promote the phosphorylation of cPLA(2)-alpha leads to (i) translocation of the enzyme from cytosol to endoplasmic reticulum, Golgi apparatus and perinuclear membranes-where it associates with the arachidonic acid in close proximity to downstream eicosanoid-producing enzymes; and (ii) the change in configuration induced by phosphorylation increases the phospholipid binding affinity and arachidonic acid release. As a mediator of growth factors, cytokines, chemokines, and hormones that modulate survival and growth in various cell types, cPLA(2)-alpha has attracted considerable attention as a potential therapeutic target in control of inflammation and cancer. The importance of the enzyme may have been underestimated by the relatively normal phenotype in the enzyme knockout animals. A clear phenotype has emerged when these knockout animals are used as models of various diseases.

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Source: http://www.hubmed.org/display.cgi?uids=18761105
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Fwd: Legal challenge to French warship dismantling in Britain (AFP via Yahoo! News)

---------- Forwarded message ----------
From: Yahoo! News Search Results for asbestos cancer <rssfwd@rssfwd.com>
Date: Thu, Sep 4, 2008 at 7:38 AM
Subject: Legal challenge to French warship dismantling in Britain (AFP via Yahoo! News)
To: mesothelioma77@gmail.com

Environmental campaigners said Wednesday they would go to the courts in a bid to stop an asbestos-contaminated French aircraft carrier from being broken up in Britain.

Wed, 03 Sep 2008 17:37:24 GMT

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Source: http://us.rd.yahoo.com/dailynews/rss/search/asbestos+cancer/SIG=1360ip4v7/*http%3A//news.yahoo.com/s/afp/20080903/sc_afp/francebritainenvironmentmilitaryshipcourt_080903173724
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