Fwd: Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells.

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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Jun 21, 2008 at 6:02 PM
Subject: Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells.
To: mesothelioma77@gmail.com


[1]Cancer Gene Ther. 2008 Jun 20;
Song W, Dong Z, Jin T, Mantellini MG, Núñez G, Nör JE

Antiangiogenic therapies have shown varying results partly because each tumor type secretes a distinct panel of angiogenic factors to sustain its own microvascular network. In addition, recent evidence demonstrated that tumors develop resistance to antiangiogenic therapy by turning on alternate angiogenic pathways when one pathway is therapeutically inhibited. Here, we test the hypothesis that expression of a caspase-based artificial death switch in tumor-associated endothelial cells will disrupt tumor blood vessels and slow down tumor progression irrespective of tumor type. Adenoviral vectors expressing inducible Caspase-9 (iCaspase-9) under transcriptional regulation with the endothelial cell-specific vascular endothelial growth factor receptor-2 (VEGFR2) promoter (Ad-hVEGFR2-iCaspase-9) induced apoptosis of proliferating human dermal microvascular endothelial cells (HDMECs), but not human tumor cells (UM-SCC-17B, head and neck squamous cell carcinoma; HepG2, hepatocellular carcinoma; PC-3, prostate adenocarcinoma; SLK, Kaposi's sarcoma; MCF-7, breast adenocarcinoma). Notably, apoptosis was dependent upon activation of iCaspase-9 with the dimerizer drug AP20187. Local delivery of Ad-hVEGFR2-iCaspase-9 followed by intraperitoneal injection of AP20187 ablated tumor microvessels and inhibited xenografted tumor growth in all tumor models evaluated here. We conclude that a cancer gene therapy strategy based on a transcriptionally targeted viral vector expressing an inducible caspase allows for selective and controlled ablation of microvessels of histopathologically diverse tumor types.Cancer Gene Therapy advance online publication, 20 June 2008; doi:10.1038/cgt.2008.38.



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Source: http://www.hubmed.org/display.cgi?uids=18566614
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Fwd: [High-risk situation - which is the best chemotherapy?]

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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Jun 21, 2008 at 6:02 PM
Subject: [High-risk situation - which is the best chemotherapy?]
To: mesothelioma77@gmail.com


[1]Gynakol Geburtshilfliche Rundsch. 2008; 48(3): 118-29
von Minckwitz G

High-risk situations in early breast cancer concern patients with less than 3 involved lymph nodes but additional risk factors as well as patients with more than 3 involved lymph nodes. For the first group, new risk assessment methods to better identify the need for chemotherapy with or without a taxane or with a taxane instead of an anthracycline are needed. For the second group, further improvement of anthracycline- or taxane-containing chemotherapy regimens is warranted. Current approaches include the sequential or simultaneous use of these groups of agents, the combination with antimetabolites, antibodies or small molecules, the neoadjuvant use of chemotherapy as well as dose-dense and dose-escalated chemotherapy regimens.



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Source: http://www.hubmed.org/display.cgi?uids=18566528
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Fwd: [Fundamental advances in the adjuvant systemic therapy of breast cancer]

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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Jun 21, 2008 at 6:02 PM
Subject: [Fundamental advances in the adjuvant systemic therapy of breast cancer]
To: mesothelioma77@gmail.com


[1]Gynakol Geburtshilfliche Rundsch. 2008; 48(3): 111-2
Fink D, Lang U, Kimmig R

In the last few decades, the notion of breast cancer has developed from a local disease rather to a systemic illness. Today radical operations can mostly be avoided by breast-conserving techniques and sentinel lymph node dissection. By the use of cytostatic and endocrine systemic therapies, an essential gain in overall survival could be obtained, too. High-risk situations can be determined and dealt with accordingly by adequate systemic therapies. Current approaches include the sequential or simultaneous use of anthracyclines and taxanes, the combination with antimetabolites, antibodies and tyrosine kinase inhibitors as well as dose-dense chemotherapeutic regimens. In the adjuvant treatment of breast cancer of postmenopausal receptor-positive patients, tamoxifen is not the gold standard anymore. An aromatase inhibitor should be used at any rate.



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Source: http://www.hubmed.org/display.cgi?uids=18566526
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Fwd: Sideshow: Winehouse's lung troubles

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Tue, Jun 24, 2008 at 6:16 AM
Subject: Sideshow: Winehouse's lung troubles
To: mesothelioma77@gmail.com

Amy Winehouse , 24, who was rushed to a London hospital after collapsing at home on June 16, must quit drugs and cigarettes or risk losing her voice - or her life - her father told the Sunday Mirror this ...

Tue, 24 Jun 2008 09:45:16 GMT

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Source: http://www.philly.com/inquirer/columnists/20080624_Sideshow__Winehouse_s_lung_troubles.html
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Fwd: Some Vegetables Cut Bladder Cancer Risk

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Tue, Jun 24, 2008 at 6:16 AM
Subject: Some Vegetables Cut Bladder Cancer Risk
To: mesothelioma77@gmail.com

Cruciferous vegetables -- broccoli, cauliflower, cabbage, Brussels sprouts, bok choy and kale -- may reduce bladder cancer risk, U.S. researchers said.

Tue, 24 Jun 2008 08:02:30 GMT

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Source: http://www.redorbit.com/news/health/1446959/some_vegetables_cut_bladder_cancer_risk/index.html
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